Grangecastle International Business Park, Kilmahudrick/Grange/Nangor Townlands, Nangor Road, Clondalkin, Dublin 22

New external Freezer Plant Platform Structure; single storey MRO Stores building within the existing construction compound; external Data Centre unit to the south of the existing Manufacturing Suites Building; airlock extension & relocated external double emergency exit doors to the south of the existing Manufacturing Suites Building; Pallet Storage building adjacent to the existing Drum Store West building within the Utility Yard and boiler Water Chemical Dosing Unit within the CUB yard and all associated site works.

Grange Castle Business Park, New Nangor Road, Clondalkin, Dublin 22

Alterations to the existing previous planning permission, no's S00A/0455 and S01A/0790, consisting of the following; proposed single storey Recycling Facility to include compactor, balers, skip and pallet handing within an enclosed yard of 624m2 approximately including a roofed area of 110m2 appromimately with a height of 3.8m., minor alterations to site works, utilities, site lighting and the like.

Wyeth Biopharma Campus, Grangecastle International Business Park, Kilmahuddrick, Grange & Nangor Townlands, Nangor Road, Clondalkin, Dublin 22

The development will consist of the construction of a new single storey Hazardous waste handling/storage building to the south of existing main buildings on site including all associated site works.

Pfizer Ireland Pharmaceuticals, Grange Castle Business Park, New Nangor Road, Clondalkin, Dublin 22

Extension to existing external freezer plant platform structure to east of existing building and associated site works.

Pfizer Ireland Pharmaceuticals, Grange Castle Busniess Park, Nangor Road, Clondalkin, Dublin 22

5 no. flag poles to existing main entrance and revised site signage and 2 no. new bicycle and smoking shelters and the permanent use of construction related bicycle shelters at the existing permitted Biotechnology Campus (Planning Ref. S00A/0455 and Planning Ref. SD03A/0643) for the manufacture and development of pharmaceutical products. This application consists of a minor variation to a previously permitted development of an activity for which a licence under Part IV of the Environmental Protection Agency Act 1992 is required.

Grangecastle International Business Park, Kilmahuddrick, Grange And Nangor Townlands, Nangor Road, Clondalkin, Dublin 22

Construct alterations and extensions to the existing permitted Biotechnology Campus for the manufacture and development of pharmaceutical products (reference previous planning permission No's. S00A/0455 and S01A/0790). The development consists of the following: a three-storey extension including roof mounted louvred screens to the previously permitted Product Development Building with new floor area of 4,263 square metres approx., a reduction in the footprint and floor area of the previously permitted Product Development Building together with revised elevations and a change to the permitted phasing of the previously permitted Product Development Building. This application consists of a minor variation to a previously permitted development of an activity for which a licence under Part IV of the Environmental Protection Agency Act, 1992 is in place: reference is made to EPA Licence No. 652 as granted on the 6th December, 2005.

Wyeth Biopharma Campus, Grange Castle International Business Park, Kilmahuddrick, Grange & Nangor Townlands, Nangor Road, Clondalkin, Dublin 22.

Replacement of existing signs in approved locations including the high level signs on the western elevation of the Drug Substance Building and the northern elevation of the Administration QAQC Building with a halo lit company logo and lettering and a face lit company logo and lettering, respectively; the non­illuminated wall mounted company sign adjacent to the entrance on the northern elevation of the Administration QAQC Building with non-illuminated company logo and lettering; the non-illuminated signs on structures on the verge of the Business Park estate road to the west of the site; and the signage on the approved internally illuminated structure on the verge at the junction of the Business Park estate roads to the north west of the site. The development for retention permission consists of the retention of a non-illuminated sign installed on a structure on the verge of the Business Park estate road to the west of the site; non-illuminated signs installed on the boundary fence adjacent to two of the entrances to the site from the Business Park estate road; non-illuminated traffic direction signs installed on traffic sign poles adjacent to the southern entrance into the site and on the verge of the Business Park estate road to the west of the site; and a wall mounted non-illuminated sign with company logo and lettering adjacent to the entrance on the western elevation to the Central Utility building.

Grange Castle Business Park, Grange, Dublin 22

Permission for development consisting of the completion of the development granted permission under Planning Application Reg. Ref. SD16A/0236 subject to the amendments and alterations to the previously approved biopharmaceutical manufacturing facility and warehouse extension and other additional, new development not forming part of SD16A/0236, located at the Pfizer site at Grange Castle Business Park, New Nangor Road; The modifications to the approved development will consist of alterations and modifications to previously approved site buildings and infrastructure required to support the proposed development they include, (a) A 6-level biopharmaceutical manufacturing building sized approximately 30,469sq.m (previously approximately 34,650sq.m) and approximately 35 metres high (previously approximately 28.2m high), with stairwells approximately 38m high, and roof-mounted plant and equipment, including solar panels; Modifications to the existing Development and Manufacturing Facility including elevational alterations and modifications to existing plant and equipment; (b) A single-storey warehouse building extension with high-bay, sized approximately 3,200 square metres (previously approximately 1,142sq.m) and approximately 17.5m high, with roof-mounted plant and equipment, including solar panels; (c) A single-storey pedestrian and materials link sized approximately 1,687sq.m (previously approximately 750sq.m) and approximately 6.95m high; (d) A new, additional 4-level extension to the existing DS1 biopharmaceutical manufacturing building, to accommodate material lifts and storage areas, sized approximately 1,925sq.m and approximately 38.2m high, to the south elevation of the existing building; (e) A new, additional single-storey chiller building sized approximately 395 square metres and approximately 6.25m high, with roof-mounted plant and equipment; (f) A new, additional single-storey plant and utilities building sized approximately 256sq.m and approximately 6.25m high, with roof-mounted plant and equipment; (g) Provision of relocated car park from its previously permitted location at the northeast of the side to a new location to the southeast of the proposed biopharmaceutical facility; including approximately 273 additional car parking spaces, including accessible car parking spaces, electric vehicle charging, motorcycle parking, dedicated car-pooling spaces and cycle parking, all accessed from the internal Grange Castle Business Park roads. Mobility parking is located adjacent and directly north of the proposed facility; (h) A relocated, single-storey security building sized approximately 60 sq.m and 6m high; (i) The proposed site infrastructure includes additional cooling towers/heat exchangers, a tank farm, pipe-bridges, surface water harvest tanks, docks and yard areas, including associated items of plant and equipment, an electric vehicle charging and solar panel substation to service photovoltaic panels over new car parking spaces, photovoltaic solar panels located over new car parking spaces, electrical generators, underground pumping facilities and internal roads and paths, fencing and site lighting, and the use of the existing Pfizer site entrance (Gate No.3) for heavy goods vehicles; (j) The development includes modifications to and the extension of, the existing internal road network within the Pfizer Campus; (k) Proposed new landscaping includes new landscaped and planted areas, replacement and reinforcement of the existing landscaping and modifications to existing berms and perimeter security fencing and gates; (l) Proposed new signage based at ground level and on the building facades on the proposed new production building; (m) The works include temporary contractor compounds, temporary car parking and the temporary use of existing site entrances during construction activities; (n) Proposed new surface water management infrastructure for the site, consisting of underground attenuation systems, rainwater harvest cisterns and distribution pipework; (o) All associated site works including sustainability features described in points (a) to (I); Planning permission for the construction of a temporary contractors car park on land to the west of the Pfizer facility with access off Grange Castle Business Park and the reinstatement of the lands to agriculture after the need for the car park expires; The application is seeking permission of 5 years for the completion of the development granted permission under PA Ref: SD16A/0236 subject to the above amendments and alterations to the previously approved Biopharmaceutical Manufacturing Facility and Warehouse and other additional, new, development not forming part of SD16A/0236; This application consists of a development for an activity for which a licence under Part IV of the Environmental Protection Agency Act 1992 (as amended by the Protection of the Environment Act, 2003) is required; An Environmental Impact Assessment Report (EIAR) accompanies this planning application.

Grange Castle Business Park, Nangor Road, Clondalkin, Dublin 22

Site signage (both building mounted and ground installed signs) and a new lobby and alterations to existing employee entrance at existing permitted Biotechnology Campus (Planning Ref: S00A/0455) for the manufacture and development of pharmaceutical products. This application consists of a minor variation to a previously permitted development of an activity for which a licence under Part IV of the Environmental Protection Agency Act, 1992 is required and will be notified to the Environmental Protection Agency.

Grangecastle International Business Park, Kilmahudrick/Grange/Nangor Townlands, Nangor Road, Clondalkin, Dublin 22

A new 5 storey bio-pharmaceutical manufacturing building to be built in two phases. Phase 1 sized 20,320sq.ms and 28.2 meters high including a single storey link sized 1,203sq.m, and Phase 2 sized 14,320sq.m and 28.2 meters high, including a single storey link sized 750sq.m, located to the south of their existing Drug Substance Building. A single storey warehouse extension located to the south of the existing warehouse including new docking facilities sized 1,142sq.m and 11.2 meter high. A three storey extension located to the east of the existing laboratory building sized 1,328sq.m and 17.6 meters high. A new south elevation with new windows on the fourth floor of the existing drug substance building. New site works including 565 new car parking spaces of which 282 are relocated car parking spaces - 282 spaces lost due to the development footprint - located to the north of the site, together with a new bicycle parking facility, a new permanent heavy goods entrance at the current construction entrance to the south boundary of the campus and new fencing, 2.1 meters high, to the east, west and south side boundaries. Permanent car parking of 350 spaces for sustaining construction and contract personnel utilising a portion of the existing temporary contractor car park. Upon completion of the construction and commissioning activities, the remainder of the contractor car park will be decommissioned. A new single storey security building sized 56sq.m and revisions and alterations to the existing road, services and landscaping and new items of plant and equipment located in the existing and proposed yards, and associated pipe bridges. All associated site works. A 10 year planning permission is sought for this proposed development. The application consists of a variation to a previously permitted development on an activity for which a licence under Part IV of the Environmental Protection Agency Act 1992 ( as amended for the Protection of the Environment Act 2003) is required and full details of the proposed development and its anticipated environmental impacts will be notified to the Environmental Protection Agency. An Environmental Impact Statement accompanies this application, and it will be avialable for inspection or purchase at the office of the Planning Authority.

Grange Castle Business Park, Nangor Road, Clondalkin, Dublin 22.